Biotin and derivatives
![Medchemexpress LLC Succinimidyl 6-[3-(2-pyridyldithio)propionamido]hexanoate | 158913-22-5 | MFCD00083163 | 98.1% | 425.52 g/mol | C18H23N3O5S2 | 1G](https://assets.fishersci.com/TFS-Assets/CCG/product-images/5000238902.png-250.jpg)
Medchemexpress LLC Succinimidyl 6-[3-(2-pyridyldithio)propionamido]hexanoate | 158913-22-5 | MFCD00083163 | 98.1% | 425.52 g/mol | C18H23N3O5S2 | 1G
Succinimidyl 6-[3-(2-pyridyldithio)propionamido]hexanoate is an alkyl/ether-based PROTAC linker containing an N-hydroxysuccinimide (NHS) ester for amine coupling and a pyridyldisulfide moiety for thiol-directed conjugation. It is used in PROTAC and bioconjugation synthesis and features a reducible disulfide that enables controlled cleavage in downstream applications.
- Provides an NHS ester for efficient conjugation to primary amines.
- Contains a pyridyldisulfide cleavable disulfide for thiol chemistry.
- Suitable as a linker in PROTAC and bioconjugation synthesis.
- Molecular formula C18H23N3O5S2; molecular weight 425.52 g/mol.
- Soluble in DMSO at approximately 50 mg/mL; may require sonication.
- Store powder at -20°C for long-term stability; solvent solutions require low-temperature storage.
- High purity (98.1%) suitable for research applications.
Medchemexpress LLC Sulfo-TAG NHS ester (disodium) | 482618-42-8 | 88.4% | 1185.12 g/mol | C43H39N7Na2O16RuS4 | 1 MG
Sulfo-TAG NHS ester (disodium) is a water-soluble N-hydroxysuccinimide (NHS) ester reagent for covalent labeling of proteins and antibodies via primary amine groups. The reagent contains a ruthenium-based electrochemiluminescent tag that enables sensitive electrochemiluminescence (ECL) detection when conjugated to antibodies. Supplied as a solid for research use; handle and store according to the supplier's SDS and COA.
- Couples to primary amine groups on proteins and antibodies for stable conjugation.
- Enables electrochemiluminescence (ECL) detection when attached to antibodies.
- Water-soluble formulation suitable for aqueous conjugation reactions.
- Provided with storage recommendations to maintain stability.
- Supplied with certificate of analysis (COA) and safety data sheet (SDS) specifying purity and molecular data.
Medchemexpress LLC Sulfo-Cy7.5 NHS ester | 2736437-44-6 | 97.0% | 1104.29 g/mol | C49H48K3N3O16S4 | 10 MG
Sulfo-Cy7.5 NHS ester is a water-soluble, hydrophilic near-infrared cyanine dye functionalized as an N-hydroxysuccinimide (NHS) ester for covalent labeling of primary amines on proteins, peptides, and other biomolecules.
- Near-infrared, water-soluble cyanine dye suitable for NIR imaging and fluorescence labeling.
- Reactive NHS ester for efficient covalent coupling to primary amines under mild conditions.
- Reported molecular weight of 1104.29 g/mol for planning conjugation ratios.
- High reported purity suitable for research applications and labeling workflows.
- Available in small milligram pack sizes for pilot studies and labeling optimization.
- Store sealed, away from moisture and light to maintain stability.
![eMolecules 1204834-00-3 | Azido-peg8-nhs ester | Combi-Blocks | MFCD13184949 | 564.589 | C23H40N4O12 | 95.000 | [N-]=[N+]=NCCOCCOCCOCCOCCOCCOCCOCCOCCC(=O)ON1C(=O)CCC1=O | 250mg | 335375127](https://assets.fishersci.com/TFS-Assets/CCG/product-images/5000190050.jpg-250.jpg)
eMolecules 1204834-00-3 | Azido-peg8-nhs ester | Combi-Blocks | MFCD13184949 | 564.589 | C23H40N4O12 | 95.000 | [N-]=[N+]=NCCOCCOCCOCCOCCOCCOCCOCCOCCC(=O)ON1C(=O)CCC1=O | 250mg | 335375127
Azido-peg8-nhs ester | Combi-Blocks | 1204834-00-3 | MFCD13184949 | 564.589 | C23H40N4O12 | 95.000 | [N-]=[N+]=NCCOCCOCCOCCOCCOCCOCCOCCOCCC(=O)ON1C(=O)CCC1=O | 250mg | 335375127
eMolecules 1353016-71-3 | DBCO-NHS ester | Ambeed | MFCD24386367 | 402.406 | C23H18N2O5 | 98.000 | O=C(CCC(=O)N1Cc2ccccc2C#Cc2ccccc12)ON1C(=O)CCC1=O | 5g | 771331422
DBCO-NHS ester | Ambeed | 1353016-71-3 | MFCD24386367 | 402.406 | C23H18N2O5 | 98.000 | O=C(CCC(=O)N1Cc2ccccc2C#Cc2ccccc12)ON1C(=O)CCC1=O | 5g | 771331422
eMolecules Hydroxy-PEG11-t-butyl ester | BroadpharmMFCD29049421 | 630.769 | C29H58O14 | 98.000 | CC(C)(C)OC(=O)CCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCO | 1g | 490840967
Hydroxy-PEG11-t-butyl ester | BroadpharmMFCD29049421 | 630.769 | C29H58O14 | 98.000 | CC(C)(C)OC(=O)CCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCO | 1g | 490840967
Medchemexpress LLC 1,2-distearoyl-sn-glycero-3-phosphoethanolamine-NHS (DSPE-NHS) | 1383932-86-2 | MFCD34561791 | 95.0% | 945.2 g/mol | C49H89N2O13P | 10 MG
DSPE-NHS is an N-hydroxysuccinimide (NHS) ester functionalized distearoyl phosphoethanolamine used for bioconjugation and liposome formation. The reagent self-assembles into lipid bilayers in aqueous solution, and the NHS ester reacts selectively with primary amines to form stable amide bonds, enabling antibody labeling and attachment of amine-containing molecules for nanoparticle and drug-delivery applications.
- Reactive NHS ester for covalent coupling to primary amines.
- Self-assembles into lipid bilayers in aqueous solution.
- Enables antibody labeling and protein conjugation.
- Suitable for liposome and nanocarrier preparation.
- Long-term storage recommended at -20 °C, sealed and protected from moisture and light.
Medchemexpress LLC Biotin-PEG5-NHS ester | 98.0% | 632.72 | 50 MG
Biotin-PEG5-NHS ester | 98.0% | 632.72 | 50 MG
Medchemexpress LLC Biotin-peg-biotin | 194920-55-3 | 99.3% | C26H44N6O6S2 | 100 MG
Biotin-PEG-Biotin is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
- Used in the synthesis of PROTACs
- Exploits the intracellular ubiquitin-proteasome system
- Selectively degrades target proteins
Medchemexpress LLC M-PEG-NHS ester (MW 10000) | 92451-01-9 | 98.0% | Poly(oxy-1,2-ethanediyl), α-[2-[(2,5-dioxo-1-pyrrolidinyl)oxy]-2-oxoethyl]-ω-methoxy- | 25 MG
m-PEG-NHS ester (MW 10000) is a PEG-based PROTAC linker. It is for research use only and not sold to patients. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins. These compounds contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein.
- Used in the synthesis of PROTACs
- Exploits the intracellular ubiquitin-proteasome system
- Selectively degrades target proteins
- Composed of PEG, alkyl, and ether groups
Medchemexpress LLC Fp-biotin | 259270-28-5 | MFCD02094222 | 99.8% | 592.75 g/mol | C27H50FN4O5PS | 5 MG
FP-Biotin is a biotin-labeled organophosphorus activity-based probe for detecting and quantifying serine hydrolase enzymes in biochemical and proteomic assays. Supplied as a solid or as a 10 mM solution in DMSO, it enables enrichment of biotinylated peptides by avidin/streptavidin capture for downstream analysis of FAAH, ABHD6, and MAG-lipase activity.
- High purity (99.8%) suitable for analytical applications.
- Biotin tag enables efficient avidin/streptavidin-based enrichment.
- Detects and quantifies serine hydrolase activity such as FAAH, ABHD6, MAG-lipase.
- Available as solid and ready-to-use DMSO solution formats.
- Compatible with plasma and proteomic workflows for biomarker discovery.
Medchemexpress LLC Bis-SS-C3-NHS ester | 98604-88-7 | 98.0% | 432.47 | C16H20N2O8S2 | 1 G
Bis-SS-C3-NHS ester is a disulfide-cleavable N-hydroxysuccinimide (NHS) ester linker used for bioconjugation and antibody-drug conjugate (ADC) synthesis. It couples to primary amines via NHS-ester chemistry and releases payloads under reducing intracellular conditions.
- Molecular weight: 432.47
- Chemical formula: C16H20N2O8S2
- Cas number: 98604-88-7
- Purity: 98.0%
- Appearance: white to off-white solid
- Reactive group: NHS ester for coupling to primary amines
- Application: cleavable disulfide linker for ADC synthesis and bioconjugation
- Available pack size: 1 g