Biotin and derivatives
Medchemexpress LLC Acetic acid, 2-(2-cyclooctyn-1-yloxy)-, 2,5-dioxo-1-pyrrolidinyl ester | 1425803-45-7 | MFCD28898688 | >95.0% | 279.29 | C14H17NO5 | 5 MG
Cyclooctyne-O-NHS ester is an NHS-activated cyclooctyne reagent used as a cleavable linker and click-chemistry reagent for in vitro bioconjugation and antibody-drug conjugate synthesis. The molecule combines a strained alkyne for azide-alkyne cycloaddition with an activated ester to enable efficient amine coupling.
- Enables azide-alkyne cycloaddition reactions for bioorthogonal conjugation.
- Activated NHS ester facilitates rapid coupling to primary amines.
- Designed for use as a cleavable linker in ADC synthesis and related conjugation workflows.
- Provided in small, laboratory-scale quantities suitable for research use.
- Accompanied by datasheet, certificate of analysis, and safety data sheet for traceability and safety.
Medchemexpress LLC Tri-GalNAc biotin | 00-00-0 | 99.8% | C83H146N14O34S | 10MG
tri-GalNAc biotin is a biotinylated asialoglycoprotein receptor (ASGPR) ligand used for lysosome-targeting chimera (LYTAC) research. It promotes ASGPR-mediated cellular uptake of neutravidin and delivers bound protein to lysosomes for degradation. Supplied as a white to off-white solid, it is highly pure and suitable for in vitro and in vivo formulation studies.
- Biotinylated ASGPR ligand for lysosomal targeting studies.
- Promotes receptor-mediated uptake of neutravidin into cells.
- High purity suitable for research applications.
- Soluble in DMSO (100 mg/mL) for in vitro use.
- Formulatable in recommended in vivo vehicles at ≥2.5 mg/mL.
- Stable as a powder at -20°C for long-term storage.
Medchemexpress LLC Bis-PEG2-NHS ester | 65869-63-8 | 99.2% | 400.34 | C16H20N2O10 | 100 MG
Bis-PEG2-NHS ester is a non-cleavable two-unit polyethylene glycol (PEG) linker intended for antibody-agent conjugation (ADC) research applications. It provides NHS ester reactive groups for coupling to amines and is used in bioconjugation workflows to construct antibody-drug conjugates.
- Non-cleavable 2-unit PEG linker for antibody-agent conjugation.
- Purity 99.24% as reported by the manufacturer.
- Molecular weight 400.34 g/mol.
- Chemical formula C16H20N2O10.
- CAS number 65869-63-8.
- Appearance solid, white to off-white.
- Storage: powder -20°C (stable for 3 years); in solvent -80°C (6 months) or -20°C (1 month).
- Package size options include 100 mg, 250 mg, 1 g, 5 g, 10 g, and 50 g.
- Manufacturer documents available: data sheet, safety data sheet, certificate of analysis, handling instructions, H NMR, RP-HPLC, and mass spectrometry data.
Medchemexpress LLC Methoxy polyethylene glycol 11 N-hydroxysuccinimide ester | 00-00-0 | MFCD28976661 | >98.0% | C28H51NO15 | 10MG
m-PEG11-NHS ester is a PEG-based linker bearing an N-hydroxysuccinimide (NHS) ester functional group that enables efficient covalent coupling to primary amines. It provides an ~11-unit PEG spacer for use in small-molecule-protein conjugation, PROTAC assembly, and other bioconjugation workflows. The product is supplied as a solid with high purity appropriate for research applications.
- NHS ester reactive toward primary amines.
- Approximately 11 ethylene glycol units provide a flexible spacer.
- Suitable for PROTAC linker synthesis and protein or peptide labeling.
- >98.0% purity as supplied.
- Molecular weight approximately 641.7; formula C28H51NO15.
Medchemexpress LLC M-PEG6-NHS ester | 1449390-12-8 | ≥97.0% | 421.44 g/mol | C18H31NO10 | 100 MG
m-PEG6-NHS ester is a non-cleavable, 6-unit polyethylene glycol (PEG) linker bearing an N-hydroxysuccinimide (NHS) activated ester. It provides a hydrophilic spacer and an activated coupling group for selective amine conjugation, and is commonly used in antibody-drug conjugate (ADC) development, PROTAC assembly, and general bioconjugation.
- Non-cleavable 6-unit PEG linker providing a hydrophilic spacer.
- Activated NHS ester for selective amine coupling.
- High purity suitable for bioconjugation (≥97.0%).
- Colorless to light yellow liquid; density approximately 1.21 g/cm3.
- Stable under cold storage: pure form -20°C (3 years) or 4°C (2 years).
- Available in lab-scale (100 mg) up to larger quantities (quote for bulk sizes).
Medchemexpress LLC Biotin-PEG4-OH | 1217609-84-1 | 98.0% | 100 MG
Biotin-PEG4-OH is a PEG-based PROTAC linker that can be utilized in the synthesis of PROTACs. It is intended for research use only and is not sold to patients.
- Molecular weight of 419.54
- Molecular formula of C18H33N3O6S
- Appears as a solid
- Color is white to off-white
- Purity is 98.0%
- Identified for laboratory chemicals and manufacturing
- Stable under recommended storage conditions
![Medchemexpress LLC Propanoic acid, 3-[2-[2-(2-azidoethoxy)ethoxy]ethoxy]-, 2,5-dioxo-1-pyrrolidinyl ester | 1245718-89-1 | 99.9% | 344.32 | C13H20N4O7 | 250 MG](https://assets.fishersci.com/TFS-Assets/CCG/product-images/5000204280.png-250.jpg)
Medchemexpress LLC Propanoic acid, 3-[2-[2-(2-azidoethoxy)ethoxy]ethoxy]-, 2,5-dioxo-1-pyrrolidinyl ester | 1245718-89-1 | 99.9% | 344.32 | C13H20N4O7 | 250 MG
N3-PEG3-C2-NHS ester is an azide-terminated polyethylene glycol (PEG3) N-hydroxysuccinimide (NHS) ester linker used for bioconjugation and the synthesis of antibody-drug conjugates (ADCs). It reacts with primary amines via NHS ester chemistry and participates in copper-catalyzed and strain-promoted azide-alkyne cycloaddition for attachment to alkyne- or DBCO/BCN-containing partners.
- Azide functional group enables copper-catalyzed and strain-promoted click reactions.
- NHS ester reacts with primary amines for efficient conjugation.
- Three-unit PEG spacer provides hydrophilicity and flexibility.
- High purity suitable for bioconjugation workflows.
- Supplied as a solid for convenient handling and storage.
Medchemexpress LLC (2,5-dioxopyrrolidin-1-yl) 3-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-propanoate | 2395839-96-8 | MFCD11041155 | 99.9% | C54H103NO28 | 10MG
m-PEG24-NHS ester is a methyl-capped polyethylene glycol (PEG) linker bearing an N-hydroxysuccinimide (NHS) activated ester. It is designed for coupling to primary amines and is commonly used as a hydrophilic spacer in the synthesis of PROTACs, bioconjugates, and other bifunctional molecules where controlled spacing and solubility are required.
- Methyl-capped PEG24 spacer with terminal NHS ester for efficient amine coupling.
- High purity suitable for synthetic and bioconjugation workflows.
- Hydrophilic and flexible linker improves solubility and reduces steric hindrance.
- Compatible with standard NHS-ester coupling conditions.
- Available in laboratory-scale quantities for research and development use.
Medchemexpress LLC Sulfo-NHS-Biotin sodium | 194041-65-1 | 95.0% | 443.43 | 1 ML
Sulfo-NHS-Biotin sodium is a low-molecular-weight (443.4 Da) tracer designed to assess blood-brain barrier permeability. It is intended for research use only.
- Low molecular weight tracer
- Assesses blood-brain barrier permeability
- Utilized in traumatic brain injury models
eMolecules 1353016-71-3 | DBCO-NHS ester | Ambeed | MFCD24386367 | 402.406 | C23H18N2O5 | 98.000 | O=C(CCC(=O)N1Cc2ccccc2C#Cc2ccccc12)ON1C(=O)CCC1=O | 1g | 595931779
DBCO-NHS ester | Ambeed | 1353016-71-3 | MFCD24386367 | 402.406 | C23H18N2O5 | 98.000 | O=C(CCC(=O)N1Cc2ccccc2C#Cc2ccccc12)ON1C(=O)CCC1=O | 1g | 595931779
Medchemexpress LLC Acridinium C2 NHS ester | 177332-37-5 | 92.1% | 632.56 | C29H23F3N2O9S | 1mg
Acridinium C2 NHS ester is a chemiluminescent label that is active for the development of protein and nucleic acid probes Acridinium C2 NHS ester can be used in bioanalysis and diagnostics to provide highly sensitive detection solutions Acridinium C2 NHS ester is widely used in medical research especially in the monitoring and analysis of biomolecules
Medchemexpress LLC Mal-PEG3-C1-NHS ester | 2230016-26-7 | 95.0% | 384.34 g/mol | C16H20N2O9 | 50 MG
Mal-PEG3-C1-NHS ester is a non-cleavable 3-unit polyethylene glycol (PEG) linker bearing a maleimide and an N-hydroxysuccinimide (NHS) ester. It is supplied for research use to facilitate conjugation between amine and thiol groups during antibody-drug conjugate (ADC) synthesis, and is provided as a solution for low-temperature storage.
- Non-cleavable 3-unit polyethylene glycol linker.
- Terminal maleimide and NHS ester functional groups for thiol and amine coupling.
- Suitable for antibody-drug conjugate (ADC) synthesis.
- Purity approximately 95.0%.
- Supplied as a solution; store at -20°C for up to 2 years.